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Alerting network alteration in isolated rapid eye movement sleep behavior disorder patients with mild cognitive

El Jeong1, Kwang Su Cha2, Hye-Rim Shin3

  • 1Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, South Korea.

Sleep Medicine
|December 5, 2021
PubMed
Abstract

Insights

Mild cognitive impairment (MCI) in isolated REM sleep behavior disorder (iRBD) patients is linked to attention network dysfunction, particularly the alerting system. Cognitive and attention deficits may be compensated for in iRBD patients without MCI.

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Cognitive Neurology

Background:

  • Isolated REM sleep behavior disorder (iRBD) is a prodromal sign of α-synucleinopathies.
  • Mild cognitive impairment (MCI) affects 30-50% of iRBD patients.
  • Parkinson's disease patients exhibit attention network deficits.

Purpose of the Study:

  • To investigate attention network function in iRBD patients with and without MCI.
  • To determine if MCI presence correlates with specific attention network dysfunctions in iRBD.

Main Methods:

  • Utilized the Attention Network Task (ANT) on 48 iRBD patients (24 with MCI, 24 without MCI) and 14 healthy controls.
  • Recorded event-related potentials (ERPs) and behavioral data during ANT.
  • Analyzed parietal N1 and P3 components to assess alerting, orienting, and executive control networks.

Main Results:

  • iRBD patients without MCI showed results comparable to healthy controls.
  • iRBD patients with MCI exhibited impaired alerting network function (p=0.130) and general cognitive decline.
  • iRBD patients with MCI demonstrated deficits in executive function and verbal memory compared to iRBD patients without MCI.

Conclusions:

  • MCI in iRBD patients is associated with impaired attention networks, especially the alerting component.
  • Cognitive and attention functions can be preserved in iRBD patients through compensatory mechanisms.
  • Attention network assessment may be valuable for understanding cognitive changes in iRBD progression.
Keywords:
Attention network taskEvent-related potentialsMild cognitive impairmentREM sleep behavior disorder

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