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Brushite bone cement containing polyethylene glycol for bone regeneration.
Ana Clara de França Silva Azevedo1, Otto Cumberbatch Morúa2, Gabriel Goetten de Lima3,4
1CERTBIO, Universidade Federal de Campina Grande (UFCG), Campina Grande, Paraíba, Brazil.
Bio-Medical Materials and Engineering
|December 5, 2021
Summary
Adding polyethylene glycol (PEG) to brushite bone cement improves handling time and temperature control without compromising bone regeneration properties. This polymer enhances bone healing in vivo.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Polymer Chemistry
Background:
- Bone cements are crucial for bone regeneration.
- Inadequate handling times can lead to complications.
- Controlling cement setting properties is essential for clinical success.
Purpose of the Study:
- To investigate the effect of polyethylene glycol (PEG) on brushite bone cement.
- To characterize PEG-modified brushite cement for handling properties and in vivo bone regeneration.
- To determine if PEG significantly alters the cement's beneficial properties.
Main Methods:
- Synthesized PEG 4000 with wollastonite via phosphorization to form brushite.
- Cured the brushite cement using oven drying.
- Characterized the cement and evaluated its performance in a rabbit tibial bone defect model in vivo.
Main Results:
- PEG addition resulted in a 60-minute handling time with minimal temperature increase during curing.
- The hardened cement contained approximately 71% brushite phase, exhibiting good compressive strength (25 MPa) and porosity (33%).
- In vivo studies showed accelerated bone neoformation by 40 days, with partial consolidation at 30 days and complete consolidation at 60 days.
Conclusions:
- Polyethylene glycol (PEG) addition does not negatively impact the beneficial properties of brushite bone cement.
- PEG serves as a viable alternative for controlling the time-temperature profile during bone cement hardening.
- The modified cement demonstrates potential for enhanced bone regeneration outcomes.
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