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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

957
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
957
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

746
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
746
Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

433
Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
433
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

885
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
885

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Related Experiment Video

Updated: Oct 11, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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New views on three-dimensional imaging technologies for glaucoma: an overview.

Maria A Guzman Aparicio1,2, Teresa C Chen1,2

  • 1Harvard Medical School.

Current Opinion in Ophthalmology
|December 5, 2021
PubMed
Summary

Three-dimensional (3D) optical coherence tomography (OCT) offers enhanced glaucoma detection. Newer 3D OCT parameters provide superior data and fewer artifacts compared to traditional 2D methods for tracking disease progression.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Early detection and monitoring of glaucoma progression are crucial for preserving vision.
  • Traditional diagnostic methods have limitations in accurately quantifying subtle structural changes.

Purpose of the Study:

  • To review advancements in three-dimensional (3D) technology for ophthalmology.
  • To explore quantitative methods used with 3D imaging.
  • To assess the efficacy of 3D technology in detecting glaucoma progression.

Main Methods:

  • Literature review of studies on 3D imaging in ophthalmology.
  • Analysis of quantitative software and algorithms for 3D data.
  • Comparison of 3D optical coherence tomography (OCT) parameters with 2D OCT.

Main Results:

  • Innovations in optical coherence tomography (OCT) imaging technology have significantly improved structural change measurements.
  • Associated quantitative software enhances the analysis of OCT data.
  • Three-dimensional (3D) OCT parameters yield more comprehensive data than two-dimensional (2D) OCT.

Conclusions:

  • Newer 3D OCT parameters offer advantages over 2D OCT parameters.
  • 3D OCT provides richer datasets and reduced artifacts in glaucoma assessment.
  • Technological advancements in 3D OCT are enhancing the detection of glaucoma disease progression.