Related Experiment Video
Updated: Oct 11, 2025
08:48
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
3.0K
Multiomics integration-based molecular characterizations of COVID-19
Chuan-Xing Li1,2, Jing Gao1,3,4, Zicheng Zhang5
1Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Briefings in Bioinformatics
|December 5, 2021
Summary
Multiomics studies reveal complex COVID-19 (coronavirus disease 2019) mechanisms. Integrating various
Area of Science:
- COVID-19 research
- Systems Biology
- Genomics and Pathobiology
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, presents unique pathobiology.
- Understanding disease mechanisms is crucial for effective interventions.
- Omics-scale studies offer potential for unraveling COVID-19 complexity.
Purpose of the Study:
- To review multiomics integration for molecular characterization of COVID-19.
- To explore how omics data aids in diagnostics and therapeutic development.
- To summarize omics investigations into pathogenesis, host genetics, and immune responses.
Main Methods:
- Integration of transcriptomics, proteomics, genomics, lipidomics, immunomics, and metabolomics.
- Application of systems biology tools for analyzing multiomics data.
- Review of existing literature on omics investigations in COVID-19.
Main Results:
- Multiomics integration provides insights into SARS-CoV-2 targets and host responses.
- Omics data aids in understanding disease pathogenesis, virulence, and host genetic factors.
- Characterization of immune and inflammatory phenotypes contributing to COVID-19 traits.
Conclusions:
- Multiomics integration is a powerful approach to understanding COVID-19 molecular mechanisms.
- This approach advances diagnostics, drug discovery, and therapeutic innovation.
- Further research combining strategies and multiomics profiling will enhance COVID-19 knowledge.
More Related Videos
Related Concept Videos
02:02Genomics
37.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.9K
01:05Single Nucleotide Polymorphisms-SNPs
16.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
16.8K
01:29Modern Molecular Taxonomy
250
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
250
01:33Proteomics
8.4K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
8.4K
01:20Applications of Molecular Taxonomy
190
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
190