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Updated: Oct 11, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Network analytics for drug repurposing in COVID-19
Nicoleta Siminea1, Victor Popescu2, Jose Angel Sanchez Martin3
1Faculty of Mathematics and Computer Science, ICUB, University of Bucharest, Romania and Department of Bioinformatics, National Institute of Research and Development for Biological Sciences, Romania.
Abstract:
To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.
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