Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rat platelet aggregation: strain and stock variations.

S D Dwyer, K M Meyers

    Thrombosis Research
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of binding of fibrinogen and annexin V to equine platelets in response to supramaximal treadmill exercise.

    Equine veterinary journal. Supplement·2002
    Same author

    Effects of sodium citrate, low molecular weight heparin, and prostaglandin E1 on aggregation, fibrinogen binding, and enumeration of equine platelets.

    American journal of veterinary research·2001
    Same author

    Use of a prestorage leukoreduction filter effectively removes leukocytes from canine whole blood while preserving red blood cell viability.

    Journal of veterinary internal medicine·2000
    Same author

    The effect of supramaximal exercise on equine platelet function.

    Equine veterinary journal. Supplement·2000
    Same author

    Plasma von Willebrand factor changes during various reproductive cycle stages in mixed-breed dogs with normal von Willebrand factor and in Doberman pinschers with type-I von Willebrand's disease.

    American journal of veterinary research·1998
    Same author

    Plasma von Willebrand factor in thoroughbreds in response to high-intensity treadmill exercise.

    American journal of veterinary research·1997
    Same journal

    Apoptotic versus procoagulant platelets: similar "necrotic" phenotype and procoagulant activity in vitro, but distinct adhesive protein composition.

    Thrombosis research·2026
    Same journal

    Heatstroke-induced coagulopathy: A scoping review of therapeutic strategies and outcome reporting.

    Thrombosis research·2026
    Same journal

    Mapping thrombus habitat: Non-contrast MRI radiomics and pixel-tile histomics approach to track venous thrombosis evolution in mice.

    Thrombosis research·2026
    Same journal

    A study protocol for a randomised controlled trial evaluating the safety and efficiency of the YEARS algorithm versus computed tomography pulmonary angiography only for suspected acute pulmonary embolism in patients with cancer: the Hydra Study.

    Thrombosis research·2026
    Same journal

    Associating the phenotypic expression of platelets with disease type through image-based single-cell profiling.

    Thrombosis research·2026
    Same journal

    The mechanisms of contractile dysfunction following chronic limited platelet activation in (pro)thrombotic conditions.

    Thrombosis research·2026
    See all related articles

    Platelet aggregation sensitivity to arachidonic acid (AA) and collagen varies significantly between rat strains, unlike adenosine diphosphate (ADP) response. NBR and Holtzman rats exhibited heightened sensitivity to AA and collagen.

    Area of Science:

    • Pharmacology
    • Hematology
    • Animal Science

    Background:

    • Platelet aggregation is crucial for hemostasis and thrombosis.
    • Variations in platelet response can be influenced by genetic factors.
    • Understanding these variations is important for preclinical research.

    Purpose of the Study:

    • To investigate differences in platelet aggregation responses among various rat stocks and strains.
    • To determine if adenosine diphosphate (ADP), arachidonic acid (AA), or collagen elicit differential aggregation patterns.
    • To explore potential correlations between platelet aggregation variability and sympathoadrenal activity.

    Main Methods:

    • Platelet aggregation was induced using ADP, AA, and collagen in rats from WSU-SD, CD, Lewis, Holtzman, and NBR groups.

    Related Experiment Videos

  • Aggregation levels were monitored and compared across the different rat stocks and strains.
  • Irreversible aggregation was quantified at specific concentrations of AA.

    • Main Results:

    • Adenosine diphosphate (ADP)-induced platelet aggregation showed no significant variation across all tested rat stocks and strains.
    • Platelet aggregation responses to arachidonic acid (AA) and collagen were dependent on the rat stock or strain.
    • Holtzman and particularly NBR rats displayed significantly higher sensitivity to AA and collagen compared to WSU-SD, CD, and Lewis rats.

    Conclusions:

    • Rat strain significantly influences platelet aggregation sensitivity to arachidonic acid and collagen, but not ADP.
    • NBR and Holtzman rats are more susceptible to platelet aggregation induced by AA and collagen.
    • Further research is warranted to elucidate the relationship between these observed platelet aggregation differences and sympathoadrenal activity.