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Acromegaly and cardiovascular outcomes: a cohort study
Sangmo Hong1, Kyung-Soo Kim2, Kyungdo Han3
1Department of Internal Medicine, Guri Hospital, College of Medicine, Hanyang University, 153, Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, Republic of Korea.
European Heart Journal
|December 5, 2021
Summary
Patients with acromegaly face increased risks of atrial fibrillation, congestive heart failure, and death. The risk for atrial fibrillation is particularly elevated within the first four years after diagnosis.
Area of Science:
- Endocrinology
- Cardiology
- Public Health
Background:
- Acromegaly, a condition of excess growth hormone, is linked to cardiovascular complications.
- Understanding the specific risks associated with acromegaly is crucial for patient management.
Purpose of the Study:
- To investigate the population-level risk of cardiovascular disease and mortality in patients with acromegaly.
- To analyze the association between acromegaly and specific cardiovascular outcomes and all-cause death.
Main Methods:
- A nationwide, retrospective, observational cohort study was conducted.
- 1874 patients with acromegaly were compared to 9370 matched controls.
- Cox proportional hazards regression was used to analyze outcomes, adjusting for multiple covariates.
Main Results:
- Patients with acromegaly showed a higher incidence of atrial fibrillation, congestive heart failure, and all-cause mortality.
- No significant difference in myocardial infarction or stroke incidence was observed between groups.
- Adjusted analyses confirmed significantly higher risks for atrial fibrillation, congestive heart failure, and all-cause mortality in acromegaly patients.
Conclusions:
- Acromegaly significantly increases the risk of atrial fibrillation, congestive heart failure, and all-cause mortality.
- The risk of atrial fibrillation demonstrates a time-dependent relationship with acromegaly, being higher in the initial years post-diagnosis.
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