Related Experiment Video

Updated: Oct 11, 2025

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

1.1K

Acromegaly and cardiovascular outcomes: a cohort study

Sangmo Hong1, Kyung-Soo Kim2, Kyungdo Han3

  • 1Department of Internal Medicine, Guri Hospital, College of Medicine, Hanyang University, 153, Gyeongchun-ro, Guri-si, Gyeonggi-do 11923, Republic of Korea.

European Heart Journal
|December 5, 2021
PubMed

Insights

Patients with acromegaly face increased risks of atrial fibrillation, congestive heart failure, and death. The risk for atrial fibrillation is particularly elevated within the first four years after diagnosis.

Area of Science:

  • Endocrinology
  • Cardiology
  • Public Health

Background:

  • Acromegaly, a condition of excess growth hormone, is linked to cardiovascular complications.
  • Understanding the specific risks associated with acromegaly is crucial for patient management.

Purpose of the Study:

  • To investigate the population-level risk of cardiovascular disease and mortality in patients with acromegaly.
  • To analyze the association between acromegaly and specific cardiovascular outcomes and all-cause death.

Main Methods:

  • A nationwide, retrospective, observational cohort study was conducted.
  • 1874 patients with acromegaly were compared to 9370 matched controls.
  • Cox proportional hazards regression was used to analyze outcomes, adjusting for multiple covariates.

Main Results:

  • Patients with acromegaly showed a higher incidence of atrial fibrillation, congestive heart failure, and all-cause mortality.
  • No significant difference in myocardial infarction or stroke incidence was observed between groups.
  • Adjusted analyses confirmed significantly higher risks for atrial fibrillation, congestive heart failure, and all-cause mortality in acromegaly patients.

Conclusions:

  • Acromegaly significantly increases the risk of atrial fibrillation, congestive heart failure, and all-cause mortality.
  • The risk of atrial fibrillation demonstrates a time-dependent relationship with acromegaly, being higher in the initial years post-diagnosis.
Abstract

Keywords:
AcromegalyAtrial fibrillationCongestive heart failureMortalityMyocardial infarctionStroke

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.1K
O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy09:24

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

3.8K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
77
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
87
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
67
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
475
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
75
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
148