Related Experiment Video
Updated: Oct 11, 2025
09:35
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
593
Acute Hyperglycemia and In-Hospital Mortality in Spontaneous Intracerebral Hemorrhage
Himanshu Gupta1,2, Simon Beshara2,3, Aristeidis Katsanos1,2
1Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Summary
Hyperglycemia (high blood sugar) is linked to increased in-hospital mortality in patients with intracerebral hemorrhage (ICH) or brain bleeds. This association persisted even after accounting for other risk factors.
Area of Science:
- Neurology
- Critical Care Medicine
- Endocrinology
Background:
- Hyperglycemia is a known predictor of poor outcomes in stroke patients.
- Intracerebral hemorrhage (ICH) is a severe type of stroke with high mortality rates.
Purpose of the Study:
- To investigate the association between acute hyperglycemia and in-hospital mortality in patients with spontaneous intracerebral hemorrhage (ICH).
Main Methods:
- Retrospective analysis of 83 consecutive ICH cases at a tertiary stroke center.
- Comparison of in-hospital mortality rates between hyperglycemic (serum glucose >7 mmol/L) and normoglycemic patients.
- Statistical adjustment for covariates including age, ICH volume, intraventricular hemorrhage, infratentorial location, and Glasgow Coma Scale.
Main Results:
- Hyperglycemia at presentation was associated with significantly higher in-hospital mortality (51.2% vs. 26.2%, OR 2.3, p=0.02).
- This association remained significant after adjusting for age, ICH volume, intraventricular hemorrhage, and ICH location.
- The association was not significant after adjusting for baseline Glasgow Coma Scale.
Conclusions:
- Acute hyperglycemia is associated with increased in-hospital mortality in patients with spontaneous ICH.
- The relationship may be indirect, potentially mediated by factors like neurological severity (e.g., Glasgow Coma Scale).
- Further research is needed to elucidate the precise mechanisms linking hyperglycemia and mortality in ICH.
Related Concept Videos
01:15Hypoglycemia and Glucagon
378
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
378
01:30Acute Pancreatitis II: Clinical Manifestations and Management
317
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
317
01:14SBAR II: Application of SBAR
5.0K
SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
5.0K
01:15Diabetes: Symptoms, Diagnosis, and Complications
1.2K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.2K