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Acute Hyperglycemia and In-Hospital Mortality in Spontaneous Intracerebral Hemorrhage

Himanshu Gupta1,2, Simon Beshara2,3, Aristeidis Katsanos1,2

  • 1Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|December 6, 2021
PubMed

Hyperglycemia is reported to predict worse outcome in patients with stroke, including intracerebral hemorrhage (ICH). In 83 consecutive cases of ICH at a tertiary stroke center, hyperglycemia (serum glucose >7 mmol/L) compared to normoglycemia at presentation was associated with higher rates of in-hospital mortality (51.2% vs. 26.2%, OR 2.3, CI 1.2-7.6, p = 0.02). The association with in-hospital mortality withstood adjustment for age, ICH volume, intraventricular hemorrhage, and infratentorial ICH location, but not baseline Glasgow Coma Scale. Acute hyperglycemia is associated with in-hospital mortality in spontaneous ICH patients, though this may be an indirect, rather than a causal relationship.

Keywords:
GlucoseHyperglycemiaIntracerebral hemorrhageMortalityPrognosis

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