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Peritoneal recurrence of colorectal cancer with microsatellite instability: Is immunotherapy alone more effective

C Gavignet¹, C Hobeika², T André³

¹Sorbonne University, department of digestive, hepato-bilio-pancreatic and liver transplantation surgery, Pitié-Salpêtrière Hospital, AP-HP, 75103 Paris, France.

Journal of Visceral Surgery

|December 6, 2021

Abstract:

A 67-year-old man was treated with systemic chemotherapy and cytoreductive surgery for microsatellite instable (MSI), deficient mismatch repair (dMMR) right colonic cancer with peritoneal metastases. Disease was controlled only when anti-PD1 and anti-CTLA4 immune checkpoint inhibitors were introduced. The patient is in complete remission after five years of follow-up. First-line immunotherapy could have a central role in the management of patients with peritoneal recurrence from MSI/dMMR colorectal cancer even though amenable to surgical treatment.

Keywords:

Anti PD-1/Anti-PDL1 Colonic adenocarcinoma Cytoreduction Hyperthermic intraperitoneal chemotherapy Immunotherapy MSI Peritoneal metastasis

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