Chloramphenicol for oral treatment of canine urinary tract infections

Chloramphenicol was administered orally for 7 to 14 days to 83 dogs with urinary tract infections. The daily dosage of 99 mg/kg (45 mg/lb) was divided into 3 equal parts and administered at 8-hour intervals. Response to treatment (negative urine culture after treatment) varied from 84% (11 to 13) for infections caused by Staphylococcus aureus to 51% (24 of 47) for those caused by Escherichia coli; 82% (14 of 17) of the infections caused by Streptococcus spp and 63% (7 of 11) of those caused by Proteus mirabilis responded to treatment. These 4 species comprised 88% of the bacteria isolated from the dogs.