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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Updated: Jul 13, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Linear scleroderma. Clinical spectrum, prognosis, and laboratory abnormalities.

V Falanga, T A Medsger, M Reichlin

    Annals of Internal Medicine
    |June 1, 1986
    PubMed
    Summary

    Linear scleroderma patients rarely develop systemic connective tissue disease. Blood eosinophilia and specific autoantibodies like anti-single-stranded DNA antibodies are linked to active and extensive disease.

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    Area of Science:

    • Dermatology
    • Rheumatology
    • Immunology

    Background:

    • Linear scleroderma is a connective tissue disease characterized by localized skin hardening.
    • Understanding its clinical manifestations and natural history is crucial for effective patient management.

    Purpose of the Study:

    • To describe the clinical features and natural history of linear scleroderma in a cohort of 53 patients.
    • To identify laboratory tests useful in managing this condition.

    Main Methods:

    • Retrospective analysis of clinical data from 53 linear scleroderma patients.
    • Evaluation of laboratory tests, including autoantibody profiles and eosinophil counts.

    Main Results:

    • No patients exhibited Raynaud's phenomenon or systemic connective tissue disease signs during a 10-year follow-up.
    • Blood eosinophilia (>300 cells/mm3) was observed in 50% of patients, correlating with active disease (p<0.02).
    • Antibodies to single-stranded DNA were present in 50% of patients, associated with extensive disease, joint contractures, and prolonged active disease (p<0.001).

    Conclusions:

    • Linear scleroderma appears to have a favorable long-term prognosis regarding systemic involvement.
    • Specific autoantibodies, including anti-single-stranded DNA antibodies, and eosinophilia are valuable biomarkers for disease activity and extent.