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Updated: Oct 11, 2025

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
Bi-atrial thrombus straddling a patent foramen ovale with bilateral embolization: A therapeutic challenge
Abhishek Dattani1,2, Kassem Safwan1, Mohammedimran Ansari1
1Department of Cardiology, Glenfield Hospital, Leicester, UK.
Insights
A rare cardiac thrombus caused a stroke and pulmonary emboli in a 55-year-old male. This case highlights the need for multidisciplinary care in managing complex cardiovascular and neurological conditions.
Area of Science:
- Cardiology
- Neurology
- Radiology
Background:
- Ischemic stroke is a major global health concern, with cardiac sources accounting for a significant proportion of cases.
- Intra-cardiac thrombus formation can lead to embolic events, including stroke and pulmonary embolism.
- Patent Foramen Ovale (PFO) is a potential pathway for paradoxical embolism.
Observation:
- A 55-year-old male presented with acute ischemic stroke and bilateral pulmonary emboli.
- Transesophageal echocardiography revealed an intra-cardiac thrombus straddling a patent foramen ovale.
- The patient's clinical presentation posed a management dilemma due to the risk of hemorrhagic transformation.
Findings:
- The intra-cardiac thrombus was identified as the source of both the ischemic stroke and pulmonary emboli.
- Echocardiography proved crucial in visualizing the thrombus and its relationship with the PFO.
- The case underscores the complexity of managing embolic events originating from cardiac sources.
Implications:
- This case emphasizes the importance of a comprehensive diagnostic approach, including advanced imaging, in identifying the source of embolic strokes.
- It highlights the challenges in managing patients with concurrent ischemic stroke and pulmonary embolism due to conflicting treatment risks.
- The findings advocate for a multidisciplinary team approach involving cardiology, neurology, and other specialists to navigate complex clinical scenarios lacking clear treatment guidelines.
Abstract:
Stroke is a leading cause of morbidity and mortality across the world and a significant portion of ischemic strokes have a cardiac source. We report a case of a 55-year-old male who presented with an ischemic stroke and bilateral pulmonary emboli secondary to an intra-cardiac thrombus straddling a patent foramen ovale, which was clearly seen using transesophageal echocardiography. We discuss the management dilemma associated with this clinical picture given the risk of hemorrhagic transformation in the acute phase of an ischemic stroke. Our case demonstrates the need for a multidisciplinary approach in an area of medicine that lacks clear guidelines.
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