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Prognostic value of interleukin-6 in atrial fibrillation: A cohort study and meta-analysis

Xiaoyue Jia1, Xi Cheng2, Na Wu1

  • 1Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University); Chongqing-People's Republic of China;Evidence-based Medicine and Clinical Epidemiology Center, Army Medical University (Third Military Medical University); Chongqing-People's Republic of China.

Anatolian Journal of Cardiology
|December 6, 2021
PubMed

Insights

Elevated interleukin-6 (IL-6) levels predict stroke and mortality in atrial fibrillation (AF) patients. Adding IL-6 to the CHA2DS2-VASc score may improve AF management strategies.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • Interleukin-6 (IL-6) is a pro-inflammatory cytokine.
  • Its prognostic value in atrial fibrillation (AF) requires further clarification.
  • AF is a common arrhythmia associated with increased risk of stroke and mortality.

Purpose of the Study:

  • To assess the predictive value of IL-6 for stroke and mortality in AF patients.
  • To evaluate the incremental prognostic value of IL-6 when added to the CHA2DS2-VASc score.
  • To validate these associations through a meta-analysis.

Main Methods:

  • A cohort study of 217 newly diagnosed non-valvular AF patients followed for 27 months.
  • Multivariate Cox regression analysis to assess IL-6 association with stroke and mortality.
  • Meta-analysis of existing cohort studies and the current study.

Main Results:

  • Elevated IL-6 was an independent predictor of stroke (HR=3.81) and mortality (HR=3.11) in the cohort.
  • Adding IL-6 to CHA2DS2-VASc score showed improved stroke prediction (AUC 0.81 to 0.88).
  • Meta-analysis confirmed IL-6 association with increased stroke (pooled HR=1.97) and mortality (pooled HR=2.73) risk.

Conclusions:

  • Increased IL-6 levels are significantly linked to higher stroke and mortality risks in AF patients.
  • IL-6 may serve as a valuable biomarker to refine AF risk stratification.
  • Incorporating IL-6 into risk scores could aid in managing AF treatment.
Abstract

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