The Distribution and Source of MRDOs Infection: A Retrospective Study in 8 ICUs, 2013-2019

Area of Science:

• Infectious Diseases
• Critical Care Medicine
• Microbiology

Background:

• Understanding the origins of multidrug-resistant organisms (MDROs) infections in intensive care units (ICUs) is vital for effective control.
• Previous studies have focused on hospital-acquired infections, but the contribution of community-acquired MDROs requires further investigation.

Purpose of the Study:

• To analyze the distribution and sources of multidrug-resistant organisms (MDROs) infections within ICUs.
• To provide data-driven insights for developing enhanced prevention and control strategies against MDROs.

Main Methods:

• A retrospective study analyzed 2629 MDRO strains from 1701 inpatients across 8 ICUs between July 2013 and June 2019.
• MDRO sources were categorized as out-of-hospital (transfer, community acquisition) and in-hospital (transfer, department acquisition).

Main Results:

• Carbapenem-resistant *Acinetobacter baumannii* (CRAB) and carbapenem-resistant *Enterobacteriaceae* (CRE) were the most prevalent MDROs.
• Out-of-hospital infections accounted for 50.51% of MDROs, with significant proportions of MRSA, CRAB, CRPA, and CRE originating from the community.
• Lower respiratory tract infections were most common (81.10%), and CRAB infections showed significant differences between comprehensive and specialized ICUs.

Conclusions:

• MDRO infections in ICUs do not solely originate from within the hospital.
• Strengthening the identification of MDRO sources is critical.
• Implementing more effective and precise infection prevention and control measures is essential.