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New Data on Variously Directed Dose-Response Relationships and the Combined Action Types for Different Outcomes of in

Vladimir Panov1,2, Tatiana Bushueva1, Ilzira Minigalieva1

  • 1Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia.

Dose-Response : a Publication of International Hormesis Society
|December 6, 2021
PubMed

Keywords:
copper-oxidedose-response relationshipshormesisnanoparticlesselenium-oxide

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Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
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The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
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When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
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