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Abnormal Brain Functional Network Dynamics in Acute CO Poisoning.

Hongyi Zheng1, Hongkun Liu1, Gengbiao Zhang1

  • 1Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University, Shantou, China.

Frontiers in Neuroscience
|December 6, 2021
PubMed
Summary

Carbon monoxide poisoning disrupts brain network dynamics in its acute phase. Children exhibit greater brain network instability than adults, impacting cognitive function and recovery.

Keywords:
acute carbon monoxide poisoningadultchildrendynamic functional network connectivity (dFNC)fMRIindependent component analysis

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Toxicology

Background:

  • Carbon monoxide poisoning can lead to severe neurological issues.
  • Previous research focused on delayed effects, overlooking acute phase brain network dynamics.
  • Understanding acute phase neural mechanisms is crucial for effective treatment.

Purpose of the Study:

  • To investigate abnormal brain network dynamics in the acute phase of carbon monoxide poisoning.
  • To explore differences in dynamic functional connectivity (dFNC) between patients and controls.
  • To analyze age-related differences in dFNC and their correlation with clinical outcomes.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (fMRI) data from 29 acute carbon monoxide poisoning patients and 29 controls.
  • Applied sliding window and k-means methods to identify dynamic functional cognitive impairment states.
  • Correlated dFNC characteristics with cognitive performance and coma duration.

Main Results:

  • Identified four distinct brain functional network connectivity patterns.
  • Patients spent more time in a state with specific network correlations (SMN-CEN positive, DMN-SMN negative).
  • Increased time in this state correlated with longer coma duration; children showed greater dFNC variability than adults.

Conclusions:

  • Acute carbon monoxide poisoning is associated with dynamic functional brain abnormalities.
  • Children exhibit more pronounced dFNC instability post-poisoning compared to adults.
  • Findings enhance understanding of acute carbon monoxide poisoning pathophysiology.