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Altered Brain Structure and Spontaneous Functional Activity in Children With Concomitant Strabismus
Xiaohui Yin1, Lingjun Chen2, Mingyue Ma1
1Department of Radiology, The Affiliated Xi'an Central Hospital of Xi'an Jiaotong University, Xi'an, China.
Frontiers in Human Neuroscience
|December 6, 2021
Summary
Children with concomitant strabismus (CS) exhibit significant brain structure and function changes. These alterations impact areas controlling vision, eye movement, and cognition, offering new insights into CS neural mechanisms.
Area of Science:
- Neuroscience
- Pediatric Ophthalmology
- Developmental Neuroscience
Background:
- Strabismus affects ~2% of children, potentially causing amblyopia and impaired depth perception.
- The long-term effects of concomitant strabismus (CS) on pediatric brain structure and function remain largely unknown.
Purpose of the Study:
- To investigate the structural and functional brain alterations in children with concomitant strabismus (CS).
- To explore the neural mechanisms underlying CS in pediatric populations.
Main Methods:
- Structural and resting-state functional magnetic resonance imaging (MRI) was performed on 26 children with CS and 28 healthy controls (HCs).
- Cortical thickness and amplitude of low-frequency fluctuation (ALFF) were analyzed to assess neuroplasticity.
Main Results:
- CS patients showed increased cortical thickness in the precentral and angular gyri, but decreased thickness in regions including the left intraparietal sulcus and temporal gyri.
- CS was associated with increased ALFF in the prefrontal cortex and superior temporal gyrus, and decreased ALFF in the caudate and hippocampus.
- Abnormalities were observed in brain regions critical for eye movement, sensory control, and higher-order cognitive functions.
Conclusions:
- Children with CS exhibit distinct structural and functional brain abnormalities.
- These findings provide novel insights into the neural underpinnings of concomitant strabismus in children.
