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Related Experiment Videos

Immune responses in rats supplemented with selenium.

L D Koller, J H Exon, P A Talcott

    Clinical and Experimental Immunology
    |March 1, 1986
    PubMed
    Summary
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    Excess selenium (Se) impacts immune function in rats, suppressing some responses while enhancing others. These findings may explain selenium

    Area of Science:

    • Immunology
    • Toxicology
    • Nutritional Science

    Background:

    • Selenium (Se) is essential for immune function, but effects of excess intake are unclear.
    • Evidence suggests Se may inhibit or promote cancer, with mechanisms unknown.
    • Understanding Se's dual role in immunity and oncogenesis is critical.

    Purpose of the Study:

    • To investigate the effects of excess selenium on specific immune functions in Se-adequate rats.
    • To explore the relationship between Se dosage and immune responses like antibody synthesis, DTH, NK cell activity, PGE2, and IL-1.
    • To provide insights into the contradictory effects of Se on cancer.

    Main Methods:

    • Female Sprague-Dawley rats were administered excess Se (0.5, 2.0, or 5.0 p.p.m.) for 10 weeks.

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  • Evaluated immune parameters included antibody synthesis, delayed-type hypersensitivity (DTH), natural killer (NK) cell activity, prostaglandin E2 (PGE2), and interleukin-1 (IL-1).
  • Compared immune function in Se-treated rats to non-Se-treated controls.

    • Main Results:

    • Enhanced splenic NK cell activity at 0.5 and 2.0 p.p.m. Se; no enhancement at 5.0 p.p.m.
    • Significant suppression of DTH response across all tested Se dosages.
    • Reduced antibody synthesis and PGE2 activity at the highest Se dosage (5.0 p.p.m.).
    • IL-1 activity remained unaffected by Se exposure.

    Conclusions:

    • Excess selenium exhibits differential effects on immune responses, potentially explaining its conflicting roles in cancer.
    • NK-sensitive tumors might benefit from Se therapy, while NK-insensitive tumors could be promoted by Se due to impaired immunity.
    • Further research is needed to elucidate the precise mechanisms underlying Se's immunomodulatory and oncogenic effects.