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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

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Tissue Engineering Strategies for Peripheral Nerve Regeneration.

Yin Li¹, Zhenjiang Ma¹, Ya Ren²

¹Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Neurology

|December 6, 2021

Summary

This summary is machine-generated.

Peripheral nerve injury (PNI) poses significant challenges. This review explores nerve tissue engineering, artificial nerves, and 3D printing for PNI repair strategies.

Keywords:

3D printing cells nerve tissue engineering pathophysiology peripheral nerve regeneration scaffolds

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Neuroscience

Background:

Peripheral nerve injuries (PNI) have severe impacts on patients' lives.
Effective therapeutic strategies for PNI remain a significant clinical challenge.
Nerve tissue engineering offers promising solutions for nerve regeneration.

Purpose of the Study:

To review the pathophysiology of peripheral nerve injuries.
To summarize tissue-engineered repairing strategies for PNI.
To highlight the role of scaffolds, seed cells, and 3D printing in neural tissue engineering.

Main Methods:

Literature review of pathophysiology and tissue-engineered repair strategies for PNI.
Discussion of scaffolds and seed cells used in neural tissue engineering.
Emphasis on the application of 3D printing in nerve tissue engineering.

Main Results:

PNI presents complex challenges requiring advanced therapeutic approaches.
Nerve tissue engineering, utilizing artificial nerves, is a key area of development.
Scaffolds, seed cells, and 3D printing are crucial components in engineered nerve repair.

Conclusions:

Tissue-engineered artificial nerves represent a vital strategy for addressing PNI.
3D printing technology shows significant potential in advancing nerve regeneration therapies.
Further research in neural tissue engineering is essential for improving PNI treatment outcomes.