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Circulating CTRP7 Is a Potential Predictor for Metabolic Syndrome.

Wenjing Hu1, Bin Zhan2, Qinge Li1

  • 1Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.

Frontiers in Endocrinology
|December 6, 2021
PubMed
Summary

Serum CTRP7 levels are elevated in metabolic syndrome (MetS) patients and correlate with disease components. This suggests CTRP7 may serve as a potential biomarker for metabolic diseases.

Keywords:
BioinformaticsCTRP7MetSinsulin resistanceinterventional tests

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Area of Science:

  • Endocrinology
  • Metabolic Research
  • Biomarker Discovery

Background:

  • Limited understanding of CTRP7's role in human metabolic diseases despite animal studies linking it to energy metabolism.
  • Need to investigate the association between CTRP7 and metabolic syndrome (MetS) in humans.

Purpose of the Study:

  • To explore the association between CTRP7 and MetS in humans.
  • To investigate the relationship between CTRP7 and components of MetS.
  • To examine CTRP7's response to metabolic interventions.

Main Methods:

  • Cross-sectional study of 624 individuals.
  • ELISA for CTRP7 and APN levels.
  • Oral glucose tolerance tests (OGTT), euglycemic-hyperinsulinemic clamp (EHC), and lipid infusion in healthy individuals.
  • Bioinformatics analysis to identify associated genes and pathways.

Main Results:

  • Serum CTRP7 was significantly higher in MetS patients than controls, correlating positively with waist circumference, blood pressure, fasting glucose, 2-hour glucose, and triglycerides, and negatively with HDL-C and APN.
  • Multivariate logistic regression confirmed CTRP7's strong correlation with MetS occurrence.
  • Intervention studies showed CTRP7 levels decreased after OGTT but increased with insulin (EHC) and free fatty acids (lipid infusion).
  • Bioinformatics analysis linked CTRP7 to metabolism-related genes and pathways.

Conclusions:

  • Elevated serum CTRP7 in MetS patients suggests its potential as a biomarker for metabolic diseases.
  • CTRP7 levels are dynamically regulated by glucose, insulin, and free fatty acid levels.
  • CTRP7 is intricately linked with whole-body metabolism through associated genes and signaling pathways.