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Paroxetine overdose during pregnancy.

Selin Acar1,2, Hilal Erol2, Elif Keskin Arslan2

  • 1Faculty of Medicine, Department of Pharmacology, Izmir Katip Celebi University, Izmir, Turkey.

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|December 6, 2021
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Summary
This summary is machine-generated.

This case report details a pregnant woman who overdosed on paroxetine (an SSRI) in early pregnancy. The infant was born healthy with normal development, suggesting potential safety despite overdose.

Keywords:
Forensic sciencescase reportforensic toxicologyoverdoseparoxetineteratogenicity

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Area of Science:

  • Perinatology
  • Pharmacology
  • Toxicology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) like paroxetine are commonly prescribed for depression and anxiety.
  • Previous epidemiological studies have yielded inconsistent findings regarding the risk of major and cardiac malformations following first-trimester paroxetine exposure.
  • Limited data exist on SSRI overdose during pregnancy, with only one prior report involving escitalopram.

Observation:

  • A 21-year-old pregnant woman intentionally ingested 300-320 mg of paroxetine hydrochloride in the 5th week of gestation.
  • The patient received prompt medical treatment for intoxication, showing no subsequent signs of maternal SSRI toxicity.
  • A teratology information service was consulted for risk assessment of potential fetal malformations.

Findings:

  • This is the first reported case of a paroxetine overdose during pregnancy.
  • The infant was born at 38 weeks gestation, weighing 3,500g, with no evidence of congenital malformations.
  • At 2 years of age, the child exhibited normal development, with no observed developmental disorders.

Implications:

  • Timely management of maternal overdose and absence of maternal toxicity may be favorable for fetal outcomes.
  • Further comprehensive studies are essential to thoroughly evaluate pregnancy outcomes following selective serotonin reuptake inhibitor overdose.
  • This case provides valuable, albeit preliminary, data on the potential impact of paroxetine overdose on fetal health.