Association of Serum High Sensitivity C-Reactive Protein With Pre-diabetes in Rural Population: A Two-Year...

Area of Science:

• Endocrinology
• Clinical Biochemistry
• Public Health

Background:

• Pre-diabetes is characterized by intermediate hyperglycemia and associated with low-grade inflammation.
• High sensitivity C-reactive protein (hsCRP) is a sensitive indicator of low-grade inflammation.
• Early diagnosis of pre-diabetes is crucial for timely intervention.

Purpose of the Study:

• To investigate the utility of hsCRP as a biomarker for the early diagnosis of pre-diabetes in a rural population.
• To assess the association between hsCRP levels and pre-diabetes status.

Main Methods:

• A case-control study involving 200 participants (100 pre-diabetes cases, 100 controls), matched for age and gender.
• Participants underwent medical history, physical examination, anthropometric measurements, and biochemical analysis including glucose, lipid profile, and hsCRP.
• Pre-diabetes diagnosis was based on World Health Organisation criteria.

Main Results:

• Mean hsCRP levels were significantly higher in pre-diabetic individuals (2.17 ± 0.72 mg/L) compared to controls (0.66 ± 0.22 mg/L) (p < 0.0001).
• hsCRP showed significant positive correlations with age, body mass index (BMI), total cholesterol, low-density lipoprotein (LDL) cholesterol, and waist-hip ratio.

Conclusions:

• Elevated hsCRP levels are associated with pre-diabetes.
• hsCRP may serve as a valuable biomarker for early pre-diabetes detection.
• hsCRP levels correlate with traditional risk factors for cardiovascular disease and diabetes.