Obesity in cystic fibrosis
Katherine A Kutney1, Zahrae Sandouk2, Marisa Desimone3
1Department of Pediatrics, Division of Pediatric Endocrinology, University Hospitals, Rainbow Babies and Children's Hospital Case Western Reserve University, 11100 Euclid Ave, Suite 737, Cleveland, OH 44106, USA.
Journal of Clinical & Translational Endocrinology
|December 6, 2021
Summary
Obesity is rising in cystic fibrosis (CF) patients, potentially increasing risks like diabetes and heart issues. Careful weight management is crucial, balancing metabolic health with lung function in CF care.
Area of Science:
- Pulmonology
- Metabolic Health
- Cystic Fibrosis Research
Background:
- Rising obesity rates in cystic fibrosis (CF) patients, with approximately one-third of adults now overweight or obese.
- Historical view of increased weight as beneficial in CF, linked to improved lung function and survival.
- Emerging concerns regarding obesity-related comorbidities in CF, such as hypertension, dyslipidemia, and insulin resistance.
Purpose of the Study:
- To review the current understanding of obesity in cystic fibrosis.
- To explore the epidemiology, contributing factors, consequences, and management strategies for obesity in CF patients.
Main Methods:
- Literature review of studies on obesity in cystic fibrosis patients.
- Analysis of factors contributing to weight gain in CF, including diet, exercise, and treatment advances.
- Examination of the relationship between body mass index (BMI) and health outcomes in CF.
Main Results:
- Obesity in CF is multifactorial, influenced by diet, reduced exercise tolerance, and therapeutic progress.
- While higher BMI was historically favorable, benefits plateau around BMI 30 kg/m² for pulmonary function.
- Obesity in CF is linked to hypertension, elevated cholesterol, and increased insulin resistance, resembling type 2 diabetes.
Conclusions:
- The optimal BMI for individuals with CF remains undetermined, necessitating a balanced approach to weight management.
- Increasing obesity rates in CF may lead to a rise in cardiovascular diseases due to longer life expectancies.
- Treatment requires careful consideration of metabolic risks versus the impact of low BMI on lung function in CF.
Keywords:
BMI, body mass indexCF, cystic fibrosisCFRD, cystic fibrosis related diabetesCFTR modulatorCardiovascular diseaseCystic fibrosisCystic fibrosis related diabetesObesityMore Related Videos
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