Related Experiment Video
Updated: Oct 11, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.7K
Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis
Xiaoyue Jia1,2, Ran Yang1,2, Jiyao Li1,3
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Frontiers in Cellular and Infection Microbiology
|December 6, 2021
Summary
Periodontitis, a bone-loss disease, is linked to gut bacteria via the gut-bone axis. Gut microbes influence systemic inflammation and immune responses, impacting bone health and periodontitis progression.
Area of Science:
- Microbiology
- Immunology
- Bone Biology
Background:
- Periodontitis is a polymicrobial infection causing alveolar bone loss.
- Systemic conditions like diabetes and osteoporosis exacerbate periodontitis.
- The gut-bone axis is increasingly recognized for its role in bone health.
Purpose of the Study:
- To review the connection between gut microbiota and periodontitis.
- To explore the mechanisms of the gut-bone axis in periodontitis pathogenesis.
- To understand how systemic diseases influence periodontitis via gut microbiota.
Main Methods:
- Literature review of existing studies on gut microbiota, periodontitis, and bone health.
- Analysis of proposed mechanisms involving microbial translocation and immune responses.
- Discussion of hormonal and metabolic influences of gut microbiota.
Main Results:
- Gut microbiota significantly impacts bone homeostasis through the gut-bone axis.
- Microbial translocation from the gut can lead to bone loss and systemic inflammation.
- Gut pathogens can trigger immune responses that contribute to periodontitis.
Conclusions:
- Gut microbiota plays a critical role in the pathogenesis of periodontitis.
- The gut-bone axis provides a framework for understanding systemic disease influence on periodontitis.
- Targeting gut microbiota may offer novel therapeutic strategies for periodontitis.
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