Related Experiment Video
Updated: Oct 11, 2025
Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Explore the Predictive Value of Peripheral Blood Cell Parameters in Refractory Mycoplasma pneumoniae Pneumonia in
Yaoyao Ling1, Jing Ning1, Yongsheng Xu1
1Department of Respiratory, Tianjin Children's Hospital, Tianjin, China.
Insights
Peripheral blood cell parameters like neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume-to-lymphocyte ratio (MPVLR) can predict refractory Mycoplasma pneumoniae pneumonia (RMPP) in children. Elevated NLR (>3.92) and MPVLR (>5.29), along with pleural effusion, are significant indicators.
Area of Science:
- Pediatric Pulmonology
- Infectious Diseases
- Hematology
Background:
- Refractory Mycoplasma pneumoniae pneumonia (RMPP) presents challenges in pediatric care.
- Identifying predictive markers for RMPP is crucial for timely intervention.
Purpose of the Study:
- To evaluate the predictive value of peripheral blood cell parameters for RMPP in children over 6 years old.
- To compare the predictive accuracy of NLR with CRP for RMPP.
Main Methods:
- Retrospective study of children with RMPP and propensity score-matched non-refractory MP (NRMPP) cases.
- Analysis of clinical characteristics, peripheral blood cell counts, imaging, and treatment data.
- ROC curve and logistic regression analysis to determine predictive factors.
Main Results:
- RMPP group showed longer clinical course and higher complication rates.
- Significantly elevated neutrophil, NLR, PLR, MPVLR, CRP, LDH, and IL-6 levels in RMPP patients.
- NLR > 3.92 (OR=3.243), MPVLR > 5.29 (OR=2.700), and pleural effusion (OR=3.023) were significant predictors of RMPP.
- NLR demonstrated higher predictive accuracy than CRP.
Conclusions:
- Peripheral blood cell parameters, specifically NLR and MPVLR, show predictive value for RMPP in children.
- NLR > 3.92, MPVLR > 5.29, and the presence of pleural effusion are key indicators for predicting RMPP.
- These findings can aid in early identification and management of RMPP.
Abstract:
Background: To determine the predictive value of peripheral blood cell parameters for refractory Mycoplasma pneumoniae pneumonia (RMPP) in children over 6 years old. Methods: A retrospective study was conducted in children with RMPP admitted to the respiratory department of Tianjin Children's Hospital from September 2017 to September 2019, and non-refractory Mycoplasma pneumoniae pneumonia (NRMPP) was selected by the propensity score method and matched according to the ratio of 1:1.5. We analyzed the differences in clinical characteristics, peripheral blood cell parameters, imaging findings, and treatments between the two groups, and further determined the predictive value of peripheral blood cell parameters on RMPP. Results: There were 76 patients in the RMPP group and 114 patients in the NRMPP group. We found that the RMPP group has a longer clinical course and a higher incidence of intrapulmonary and extrapulmonary complications (p < 0.01). Moreover, the proportion of children in the RMPP group who received immunotherapy (such as glucocorticoid, gamma immunoglobulin) and fiberoptic bronchoscopy intervention was higher than that in the NRMPP group (p < 0.01). Meanwhile, the level of neutrophil, neutrophil/lymphocyte ratio (NLR), platelet count/lymphocyte ratio (PLR), mean platelet volume/lymphocyte ratio (MPVLR), C-reactive protein (CRP), lactic dehydrogenase (LDH), and interleukin (IL)-6 in the RMPP group was significantly higher (p < 0.01) than those in the NRMPP group. The incidence of pulmonary consolidation, atelectasis, and pleural effusion was also higher in the RMPP group (p < 0.05). ROC curve and binary logistic regression analysis showed that NLR > 3.92 (OR = 3.243; 95% CI = 1.485-7.081; p = 0.003), MPVLR > 5.29 (OR = 2.700; 95% CI = 1.258-5.795; p = 0.011), and pleural effusion (OR = 3.023; 95% CI = 1.424-6.420; p = 0.004) were significant factors in predicting RMPP. Our study showed that NLR had higher accuracy in predicting RMPP than CRP. Conclusions: The parameters of peripheral blood cells might be a predictor of RMPP. NLR > 3.92, MPVLR > 5.29, and pleural effusion might have important predictive value for RMPP in children over 6 years old.
