What's the Cost? Measuring the Economic Impact of Pediatric Sepsis

Related Experiment Video

Updated: Oct 11, 2025

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

11.3K

Erin F Carlton1,2, Scott L Weiss3,4, Hallie C Prescott5,6

  • 1Division of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI, United States.

Frontiers in Pediatrics
|December 6, 2021
PubMed

Insights

Pediatric sepsis hospitalization impacts families long-term. This study explores family spillover effects, their importance, and measurement methods for better caregiver support.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Family medicine

Background:

  • Sepsis affects nearly 75,000 children annually in the US, causing life-threatening organ dysfunction.
  • While most children survive sepsis, long-term consequences for children and families are increasingly recognized.
  • These consequences encompass medical, psychosocial, and financial burdens on the entire family unit.

Purpose of the Study:

  • To describe family spillover effects in pediatric sepsis.
  • To emphasize the importance of measuring these effects on caregivers.
  • To outline methods for quantifying family spillover effects.

Main Methods:

  • Literature review and conceptual framework development.
  • Analysis of existing research on pediatric sepsis outcomes.
  • Identification of measurement tools and strategies for family impact.

Main Results:

  • Pediatric sepsis generates significant spillover effects on family members and caregivers.
  • These effects manifest across multiple domains including emotional, financial, and social well-being.
  • Standardized measurement is crucial for understanding the full scope of family impact.

Conclusions:

  • Family spillover effects are a critical, yet often overlooked, aspect of pediatric sepsis.
  • Accurate measurement is essential for developing targeted interventions and support systems.
  • Addressing family impacts can improve overall recovery and well-being for sepsis-affected children and their relatives.

Keywords:
familyfinancesfinancial toxicitypediatricsepsis

More Related Videos

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.5K
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.2K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
27
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
20
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
19
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
18
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
32
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
180