Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

6.4K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.4K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

81
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
81
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.0K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.0K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

451
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
451

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Responsible Use of Large Language Models in Microbial Genomics and Bioinformatics: A Life-Science Framework for Reliability, Reproducibility, and Risk-Aware Interpretation.

Life (Basel, Switzerland)·2026
Same author

Comparative ASCL1 interactome analysis reveals CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified neuroblastoma.

Molecular cancer research : MCR·2026
Same author

Patterns and Trends of Colorectal Cancer in the United Arab Emirates: A Retrospective Cohort Study, 2012-2021.

The Gulf journal of oncology·2026
Same author

Health systems science education for undergraduate medical students: a 3-year longitudinal curriculum preparing students to drive real-world health system improvement.

BMC medical education·2026
Same author

Differential roles of coding and non-coding transcripts in obesity: insights from RNA-seq analysis of Macaca fascicularis hepatocytes.

BMC genomics·2025
Same author

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.

Cell host & microbe·2025

Related Experiment Video

Updated: Oct 11, 2025

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

9.0K

Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis.

Shakhzada Ibragimova1, Revathy Ramachandran1, Fahad R Ali1

  • 1College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Healthcare City, Dubai, UAE.

Frontiers in Cell and Developmental Biology
|December 6, 2021
PubMed
Summary

Diet impacts gut microbes, influencing cancer risk. Healthier diets promote beneficial bacteria, reducing cancer, while Western diets may increase risk by altering the gut microbiome.

Keywords:
Western dietalcoholcolorectal cancerdietary patternmicrobiomeoncogenesisplant-based diet

More Related Videos

Characterization and Functional Prediction of Bacteria in Ovarian Tissues
10:12

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

2.9K
A Proximal Culture Method to Study Paracrine Signaling Between Cells
08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

9.7K

Related Experiment Videos

Last Updated: Oct 11, 2025

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

9.0K
Characterization and Functional Prediction of Bacteria in Ovarian Tissues
10:12

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

2.9K
A Proximal Culture Method to Study Paracrine Signaling Between Cells
08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

9.7K

Area of Science:

  • Microbiome research
  • Cancer biology
  • Nutritional science

Background:

  • Rising cancer incidence is linked to lifestyle factors like obesity and metabolic syndrome.
  • These conditions correlate with significant alterations in the gut microbiome's composition and function.
  • The gut microbiome plays a definable role in health and disease, interacting with molecular pathways involved in cancer.

Purpose of the Study:

  • To review how dietary patterns influence gut microbial populations.
  • To illustrate the impact of microbial metabolites on cancer development pathways.
  • To connect dietary habits, microbiome changes, and cancer risk.

Main Methods:

  • Literature review of studies examining diet, gut microbiome, and cancer.
  • Analysis of research correlating habitual diets with fecal microbiome signatures and metabolic health markers.
  • Synthesis of findings on bacterial products and their effects on molecular pathways.

Main Results:

  • Plant-based diets are associated with increased short-chain fatty acid producers, improved metabolic markers, and lower cancer risk.
  • Western diets are linked to reduced intestinal defenses and promotion of bacteria involved in carcinogenic pathways.
  • Specific microbial signatures correlate with habitual diets and metabolic health.

Conclusions:

  • Dietary patterns significantly shape the gut microbiome.
  • Microbial metabolites derived from diet influence both local and systemic cancer development.
  • Understanding these diet-microbiome-cancer interactions is crucial for developing preventive strategies.