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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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The EU Response to the Presence of Nitrosamine Impurities in Medicines

Robin Ruepp1, Roland Frötschl2, Robert Bream1

  • 1European Medicines Agency, Human Medicines Division, Amsterdam, Netherlands.

Frontiers in Medicine
|December 6, 2021
PubMed

Keywords:
carcinogenicityhuman medicineslinear extrapolationmetforminnitrite (NaNO2)nitrosaminesranitidinesartans

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