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Updated: Oct 11, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers

Song Wang1, Yufan Ying1, Xueyou Ma1

  • 1Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Frontiers in Molecular Biosciences
|December 6, 2021
PubMed

Insights

Circular RNAs (circRNAs), stable noncoding molecules, are increasingly linked to cancer development and progression. This review focuses on their role in urological cancers, exploring therapeutic potential.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are a class of noncoding RNAs with a stable loop structure.
  • Dysregulation of circRNAs is implicated in various human diseases, particularly cancers.
  • circRNAs influence key cancer processes like proliferation, migration, drug resistance, and immune escape.

Purpose of the Study:

  • To systematically review the biogenesis and characteristics of circRNAs.
  • To highlight the mechanisms and clinical applications of circRNAs in urological cancers.
  • To identify potential therapeutic targets for urological cancer treatment.

Main Methods:

  • Literature review and systematic summary of existing research on circRNAs.
  • Focus on circRNAs' role in biological processes relevant to cancer.
  • Analysis of circRNAs as diagnostic and prognostic biomarkers in oncology.

Main Results:

  • circRNAs are stable molecules with significant roles in tumor progression.
  • circRNAs are implicated in proliferation, migration, drug resistance, and immune evasion in cancers.
  • circRNAs show promise as biomarkers for cancer diagnosis and prognosis.

Conclusions:

  • circRNAs are crucial in urological cancer pathogenesis.
  • Understanding circRNA mechanisms can lead to novel therapeutic strategies.
  • circRNAs represent promising targets for future urological cancer therapies.
Keywords:
biomarkercircular RNAsmechanismtherapy targetsurological cancers

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