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Association Between Left Ventricular Global Function Index and Outcomes in Patients With Dilated Cardiomyopathy

Tong Liu1,2,3, Zhen Zhou4, Kairui Bo4

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Frontiers in Cardiovascular Medicine
|December 6, 2021
PubMed

Insights

Left ventricular global function index (LVGFI) measured by cardiac magnetic resonance (CMR) predicts better outcomes in dilated cardiomyopathy (DCM) patients. Higher LVGFI is linked to fewer major adverse cardiac events (MACEs), indicating its prognostic value in heart failure.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Heart Failure Research

Background:

  • Left ventricular global function index (LVGFI) assessed by cardiac magnetic resonance (CMR) shows promise for predicting clinical outcomes.
  • The prognostic role of LVGFI in heart failure (HF) patients with dilated cardiomyopathy (DCM) remains uncertain.

Purpose of the Study:

  • To investigate the association between LVGFI and clinical outcomes in patients with DCM.
  • To determine if LVGFI can predict major adverse cardiac events (MACEs) in this patient population.

Main Methods:

  • A prospective cohort study involving 334 consecutive DCM patients who underwent CMR between January 2015 and April 2020.
  • LVGFI was the primary exposure variable, with outcomes assessed using multivariable models adjusted for confounders.
  • The composite endpoint included death or heart transplantation over a median follow-up of 565 days.

Main Results:

  • Patients with LVGFI below 15.73% had a significantly higher incidence of the composite endpoint (P = 0.0021).
  • Each 1 SD increase in LVGFI was associated with a 38% decrease in MACEs (HR 0.62), and this association persisted after adjustment (46% decrease, HR 0.54).
  • Subgroup analyses confirmed the consistency of these findings.

Conclusions:

  • Increased CMR-assessed LVGFI is associated with a reduced long-term risk of MACEs in patients with DCM.
  • LVGFI serves as a valuable prognostic marker in DCM, independent of traditional risk factors.
  • These findings support the utility of LVGFI in risk stratification for DCM patients.

Keywords:
association analysiscardiac magnetic resonance imagingclinical outcomesdilated cardiomyopathyleft ventricular global function index

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