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Meeting Report: Vaccine Stability Considerations to Enable Rapid Development and Deployment.

Mark Alasandro1, Dilip Choudhury2, Kim Huynh-Ba3

  • 1Adamis Pharmaceuticals, San Diego, CA USA.

AAPS Open
|December 6, 2021
PubMed
Summary

This workshop reviewed vaccine stability challenges for rapid development and deployment. Key topics included analytical characterization, stability modeling for Emergency Use Authorization (EUA), and distribution strategies.

Keywords:
COVID-19Drug Product TransportFreeze-Thaw StudyIn-Use StudyLast-MilePharmaceutical Supply ChainPlatform TechnologiesRapid DeploymentRapid DevelopmentShipping StudyStabilityStability ModelingVaccine Development

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Area of Science:

  • Pharmaceutical Sciences
  • Vaccinology
  • Regulatory Science

Background:

  • The American Association of Pharmaceutical Scientists (AAPS) Stability Community convened a virtual workshop on vaccine stability.
  • The workshop focused on accelerating vaccine development and deployment during the pandemic.

Purpose of the Study:

  • To review key topics discussed at the AAPS workshop on vaccine stability.
  • To highlight challenges and strategies for rapid vaccine development, characterization, and deployment.

Main Methods:

  • Review of presentations and panel discussions from the AAPS virtual workshop.
  • Synthesis of information on vaccine stability considerations, analytical characterization, and modeling.

Main Results:

  • Discussion of challenges in accelerating vaccine development and analytical techniques for shelf-life determination.
  • Exploration of vaccine stability modeling for Emergency Use Authorization (EUA) approaches.
  • Emphasis on the role of stability studies in vaccine distribution and pandemic response.

Conclusions:

  • Techniques discussed are broadly applicable to various vaccine types, including mRNA vaccines.
  • Expert insights were shared on EUA approval and deployment challenges for novel vaccine technologies.