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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
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SARS-CoV-2 at the human-animal interphase: A review
Elmoubasher A Farag1, Md Mazharul Islam2, Khalid Enan2
1Ministry of Public Health, Doha, Qatar.
Heliyon
|December 6, 2021
Summary
The origin and animal hosts of SARS-CoV-2 (the virus causing COVID-19) remain unclear, complicating prevention. Understanding the human-animal interface is crucial for effective control strategies.
Area of Science:
- Veterinary Medicine
- Epidemiology
- Zoonotic Diseases
Background:
- COVID-19, caused by SARS-CoV-2, emerged in 2019 with zoonotic origins, but the precise spillover source and intermediate hosts are unidentified.
- The emergence of new susceptible animal species raises concerns about viral replication and potential intra- and interspecies transmission, complicating public health efforts.
- Mapping disease patterns requires understanding the role of animals and their products in SARS-CoV-2 epidemiology.
Purpose of the Study:
- To review current knowledge on SARS-CoV-2 infection at the human-animal interface.
- To explore the genetic relatedness and origins of SARS-CoV-2 variants in animals.
- To assess the role of animals and their products in disease transmission and discuss contamination potential.
Main Methods:
- Literature review of recent updates on SARS-CoV-2 at the human-animal interface.
- Analysis of postulations regarding the genetic origins of animal-isolated SARS-CoV-2 variants.
- Examination of studies on animal roles in transmission, virus contamination, and environmental stability.
Main Results:
- The review synthesizes information on SARS-CoV-2 susceptibility in various animal species and its implications for disease spread.
- Evidence regarding the potential role of animal products in SARS-CoV-2 transmission is discussed.
- Current prevention and management strategies for SARS-CoV-2 are reviewed.
Conclusions:
- Further research into the epidemiology of SARS-CoV-2 at the human-animal interface is essential for effective prevention and control.
- One Health-based control measures are proposed as a valuable approach for managing future zoonotic disease threats.
- Identifying the source and understanding animal involvement are critical for mitigating the impact of SARS-CoV-2.
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