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Updated: Oct 11, 2025

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
Published on: August 17, 2017
Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
Mehmet Okçu1, Fatmanur Aybala Koçak1, Samet Sancar Kaya1
1Department of Physical Medicine and Rehabilitation, Ahi Evran University School of Medicine, Kırşehir, Turkey.
Abstract:
Bisphosphonates are commonly used in the treatment of osteoporosis. Atypical femoral fracture (AFF) is a well-known adverse effect of bisphosphonate use. The importance of genetic factors has been demonstrated in bone quality, bone turnover, and in the response to osteoporosis treatment. Herein, we present two cases of bilateral AFFs after bisphosphonate use for a short period of time in members of the same family (mother and her daughter) and discuss genetic predisposition to bisphosphonate-induced AFFs in the light of literature data.
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