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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration.

Aziz Maleki1, Jiahui He2, Shayesteh Bochani1

  • 1Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), and Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran.

ACS Nano
|December 6, 2021
PubMed
Summary

Multifunctional photoresponsive hydrogels (MPRHs) combine light-based therapies like photothermal therapy (PTT) and photodynamic therapy (PDT) with hydrogel properties for advanced wound repair. This review explores MPRHs for enhanced wound regeneration and infection control.

Keywords:
antibacterial hydrogelsmultifunctional hydrogelsphotodynamic agentsphotoresponsive hydrogelsphotosensitizersphotothermal agentstissue regenerationwound dressingwound healing

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Photomedicine

Background:

  • Light-based therapies, including photothermal therapy (PTT) and photodynamic therapy (PDT), are crucial in modern medicine for wound management.
  • Hydrogels offer significant advantages as wound dressings due to their biocompatibility and therapeutic potential.
  • Multifunctional photoresponsive hydrogels (MPRHs) integrate light-responsive materials with hydrogel platforms for advanced wound care applications.

Purpose of the Study:

  • To provide a comprehensive review of multifunctional photoresponsive hydrogels (MPRHs) for wound regeneration.
  • To discuss various types of MPRHs based on different photosensitizers, photothermal agents (PHTAs), and photodynamic agents (PHDAs).
  • To explore the therapeutic mechanisms of PTT, PDT, and synergistic therapies in modulating the wound microenvironment for infection control and tissue repair.

Main Methods:

  • Review and synthesis of existing literature on MPRHs for wound healing.
  • Categorization of MPRHs based on their constituent photosensitive agents (PHTAs and PHDAs).
  • Discussion of therapeutic strategies including PTT, PDT, and combined photothermal/photodynamic therapy.

Main Results:

  • Diverse MPRHs can be prepared using various PHTAs (e.g., transition metal nanomaterials, carbon-based materials) and PHDAs (e.g., ZnO, black phosphorus, TiO2, organic molecules).
  • PTT and PDT effectively inhibit bacterial infection by modulating the wound microenvironment.
  • Synergistic photothermal/photodynamic therapies offer enhanced therapeutic outcomes for wound management.

Conclusions:

  • MPRHs demonstrate significant potential for wound regeneration by combining therapeutic effects with tissue repair capabilities.
  • Further research is needed to address existing challenges and explore future directions in MPRH development for wound management.
  • MPRHs represent a promising platform for advanced wound care, offering multifaceted therapeutic benefits.