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Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in

Lai Shunkai1,2, Ting Su1,3, Shuming Zhong2

  • 1Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.

Psychological Medicine
|December 6, 2021
PubMed
Abstract

Insights

Major depressive disorder (MDD) with melancholic features shows altered hippocampus connectivity. This dysfunction, particularly involving the hippocampus and cerebellum, is linked to working memory deficits in patients.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Previous research indicates hippocampal structural and functional changes in major depressive disorder (MDD).
  • Dynamic functional connectivity (dFC) of hippocampal subregions in melancholic MDD has not been previously analyzed.
  • This study investigates dFC variability in hippocampal subregions and its association with cognitive impairment in melancholic MDD.

Purpose of the Study:

  • To analyze dFC variability in hippocampal subregions (rostral and caudal) in melancholic MDD.
  • To examine the association between altered dFC and cognitive impairments in this patient group.
  • To identify potential neural substrates underlying cognitive deficits in melancholic MDD.

Main Methods:

  • Utilized sliding-window analysis to assess whole-brain dFC for hippocampal subregion seeds.
  • Included 42 treatment-naive melancholic MDD patients and 55 healthy controls.
  • Assessed cognitive performance using the MATRICS Consensus Cognitive Battery (MCCB) and conducted association analyses.

Main Results:

  • Melancholic MDD patients exhibited decreased dFC variability between the left rostral hippocampus and left anterior cerebellum compared to controls.
  • Patients showed poorer cognitive performance in working memory, verbal learning, visual learning, and social cognition.
  • Working memory performance positively correlated with left rostral hippocampus-left anterior cerebellum dFC variability in MDD patients.

Conclusions:

  • Confirmed distinct dynamic functional pathways involving hippocampal subregions in melancholic MDD.
  • Suggests hippocampus-cerebellum connectivity dysfunction underlies working memory impairment in melancholic MDD.
  • Highlights the role of specific neural pathways in cognitive deficits associated with melancholic depression.
Keywords:
Cerebellumcognitive impairmentdynamic functional connectivityhippocampal subregionsmajor depressive disordermelancholic depression

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