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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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[Thermoregulatory dysfunction in Parkinson's disease].

I I Coloman1, O S Levin1

  • 1Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|December 6, 2021
PubMed
Summary

Thermoregulatory dysfunction is a common autonomic disorder in Parkinson disease, impacting temperature balance due to dopamine deficiency and nervous system issues. Early detection and treatment can significantly improve patient quality of life.

Keywords:
Parkinson’s diseasesudomotor dysfunctionthermoregulation

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Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Thermoregulatory dysfunction is under-investigated in Parkinson disease (PD).
  • Pathophysiology involves central and peripheral nervous system mechanisms.
  • Dopamine deficiency and autonomic dysfunction disrupt temperature balance in PD.

Purpose of the Study:

  • To highlight the significance of thermoregulatory dysfunction in Parkinson disease.
  • To explore the central and peripheral mechanisms involved.
  • To emphasize the role of dopaminergic innervation in thermoregulation.

Main Methods:

  • Review of pathophysiological mechanisms.
  • Discussion of clinical symptoms related to temperature imbalance.
  • Evaluation of current thermoregulatory tests.

Main Results:

  • Thermoregulatory dysfunction is linked to dopamine deficiency and autonomic issues in PD.
  • Preoptic-anterior hypothalamus dopaminergic innervation is critical for central thermoregulation.
  • Thermoregulatory tests can identify sudomotor and heat dissipation disorders.

Conclusions:

  • Thermoregulatory tests aid in diagnosing PD and differentiating it from other neurodegenerative disorders.
  • Early identification and management of thermoregulatory dysfunction improve quality of life for PD patients.