Related Experiment Video
Updated: Oct 11, 2025

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions
Published on: January 7, 2019
Serendipity Reveals the Function and Physiological Role of a Large Family of Proteins
1Microbiology Department, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Abstract:
Microbial metabolism involves a complex set of interactions between metabolic pathways that include proteins of both known and uncharacterized function. While investigating the physiological strategy used by actinomycetes with two RpoB paralogs, Damiano et al. uncovered the endonuclease activity of a member of the Rid family (F. Damiano, M. Calcagnile, D. Pasanisi, A. Talà, et al., J Bacteriol, 204:e00462-21, 2022, https://doi.org/10.1128/JB.00462-21). While this finding was peripheral to the original question posed by the authors, it has considerable significance. The study by Damiano et al. highlights how unexpected, but fundamental, information can be gained by following phenotypic leads.
Related Concept Videos
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
Signal Sequences and Sorting Receptors
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Directing Proteins to the Rough Endoplasmic Reticulum
Protein Families
The Unfolded Protein Response

