Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Other Pulmonary Disorders

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeting the neutrophil-DPP-1-protease axis in airway disease: current evidence and future indications.

Respiratory medicine·2026

Same author

Twelve-Month Real-World Outcomes of Tezepelumab in Severe Asthma: Clinical Remission, Biomarker Changes, and Trigger Burden-A SANI Multicenter Cohort.

Journal of personalized medicine·2026

Same author

Use of modified Viegas capsuloplasty for chronic scapholunate Geissler 3C lesions: long-term follow-up on 338 patients.

The Journal of hand surgery, European volume·2026

Same author

Use of an Anti-Thymic Stromal Lymphopoietin Agent in Patients With Asthma and Clinically Significant Bronchiectasis: A Case Series.

Chest·2026

Same author

Impact of Biologics Administered for Severe Asthma on T2-comorbidities: A Narrative Review.

Archivos de bronconeumologia·2026

Same author

Clinical remission in allergy and clinical immunology practice: State of the art and World Allergy Organization (WAO) call to action.

The World Allergy Organization journal·2026

Search research articles

Related Experiment Video

Updated: Oct 11, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Severe asthma: One disease and multiple definitions.

Diego Bagnasco¹, Pierluigi Paggiaro², Manuela Latorre^2,3

¹Allergy and Respiratory Diseases, Department of Internal Medicine (DIMI), IRCCS Policlinico San Martino, University of Genoa, Italy.

The World Allergy Organization Journal

|December 6, 2021

Summary

This summary is machine-generated.

Different definitions of severe asthma lead to varied patient classifications. The Global Initiative for Asthma (GINA) definition aligns with the American Thoracic Society/European Respiratory Society (ATS/ERS) criteria, potentially simplifying access to advanced therapies.

Keywords:

Biological treatment Classification Definition Severe asthma

More Related Videos

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: Oct 11, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Pulmonology
Clinical Medicine
Asthma Research

Background:

No universal definition of severe asthma exists, leading to varied patient classification based on exacerbations, medication, and lung function.
Current definitions rely on parameters that differ across guidelines, causing inconsistencies in identifying severe asthma cases.
This heterogeneity complicates patient management and access to specialized treatments.

Purpose of the Study:

To evaluate how different severe asthma definitions impact patient classification.
To compare patient allocation across established severe asthma criteria.

Main Methods:

Analysis of data from the Severe Asthma Network Italy (SANI) registry.
Reclassification of patients using definitions from U-BIOPRED, NICE, WHO, ATS/ERS, GINA, ENFUMOSA, and TENOR.

Main Results:

Significant variation in patient numbers across definitions: ATS/ERS and GINA identified the most (86%), while WHO identified the fewest (23%).
Mean eosinophil counts varied, with NICE showing the highest (624 cells/mcL) and ATS/ERS, U-Biopred, and Enfumosa showing similar levels (around 516-532 cells/mcL).
Lung function (FEV1) showed minor variations, with WHO having the lowest mean (67%) and ATS/ERS-GINA the highest (73%).

Conclusions:

The study highlights significant heterogeneity in patient distribution based on severe asthma definitions.
The recent GINA definition aligns closely with the 2014 ATS/ERS criteria, offering a more consistent patient reclassification.
Adopting a standardized definition, like the GINA/ATS/ERS approach, may help overcome classification inconsistencies and improve access to biological therapies.