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Updated: Oct 11, 2025
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Published on: April 27, 2021
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Long-lived Humans Have a Unique Plasma Sphingolipidome
Irene Pradas1, Mariona Jové1, Kevin Huynh2
1Department of Experimental Medicine, University of Lleida-Lleida Biomedical Research Institute (UdL-IRBLleida), Lleida, Catalonia, Spain.
Summary
Human longevity is linked to a unique lipidome profile. Centenarians show higher complex glycosphingolipids and lower ceramide species, suggesting structural lipids are key to exceptional lifespan.
Area of Science:
- Biochemistry
- Gerontology
- Metabolomics
Background:
- Species-specific lipidome profiles are associated with animal longevity.
- Human longevity research lacks comprehensive lipidomic studies.
Purpose of the Study:
- To define the lipidomic phenotype of healthy centenarians.
- To investigate the role of sphingolipids in human exceptional lifespan.
Main Methods:
- Mass spectrometry-based lipidomics.
- Detection and quantification of 151 sphingolipid molecular species.
Main Results:
- Centenarians exhibit higher levels of complex glycosphingolipids (hexosylceramides, gangliosides).
- Centenarians show lower levels of de novo pathway ceramides, sphingomyelin, and sulfatides.
- Levels of ceramide-derived signaling compounds remained unchanged in centenarians.
Conclusions:
- Structural glycosphingolipids may play a more significant role in achieving centenarian status than signaling sphingolipids.
- This study defines a distinct lipidomic signature associated with human longevity.
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