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Updated: Oct 11, 2025

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Hormesis and neural stem cells.

Edward J Calabrese1, Vittorio Calabrese2, Gaurav Dhawan3

  • 1Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts; Amherst, MA, 01003, USA.

Free Radical Biology & Medicine
|December 6, 2021
PubMed
Summary
This summary is machine-generated.

Hormetic dose responses, a beneficial low-dose effect, are common in neural stem cells (NSCs). Various agents stimulate NSC proliferation and differentiation, offering therapeutic potential for neurological conditions.

Keywords:
Biphasic dose responseCell differentiationCell proliferationHormesisNeural stem cellStem cell

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Toxicology

Background:

  • Neural stem cells (NSCs) are crucial for brain development and repair.
  • Hormesis describes a biphasic dose-response where low doses stimulate and high doses inhibit biological functions.
  • Understanding hormetic effects in NSCs is vital for neurological health and disease management.

Purpose of the Study:

  • To identify and assess hormetic dose responses in neural stem cells (NSCs).
  • To explore the impact of various agents on NSC proliferation and differentiation.
  • To evaluate the therapeutic potential of hormetic strategies for neurological disorders.

Main Methods:

  • Review and synthesis of existing literature on hormetic dose responses in NSCs.
  • Analysis of data from animal models and human tissues.
  • Identification of agents known to induce hormetic effects in NSCs.

Main Results:

  • Hormetic dose responses were frequently observed in NSCs across various studies.
  • Agents including dietary supplements, pharmaceuticals, endogenous ligands, environmental contaminants, and physical factors induced hormesis.
  • These responses were linked to enhanced NSC proliferation, differentiation, and resilience to inflammatory stress.

Conclusions:

  • Numerous agents can induce hormetic effects in NSCs, upregulating key functions.
  • Hormetic frameworks hold significant therapeutic promise for treating neurological injury and diseases.
  • Further research into hormetic mechanisms could unlock novel clinical applications.