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Epigenetic Reprogramming and Landscape of Transcriptomic Interactions: Impending Therapeutic Interference of

Suman Kumar Ray1, Sukhes Mukherjee1

  • 1Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh-462020, India.

Current Molecular Medicine
|December 7, 2021
PubMed

Insights

Epigenetics and transcriptomics are key to understanding triple-negative breast cancer (TNBC) development and treatment. Research into these areas offers new diagnostic and therapeutic strategies for this aggressive cancer.

Area of Science:

  • Oncology and Molecular Medicine
  • Cancer Epigenetics
  • Transcriptomics in Cancer Research

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with poor clinical outcomes, characterized by hereditary factors and epigenetic modifications.
  • Epigenetic deregulation, including DNA methylation and histone modification, plays a crucial role in early carcinogenesis, cell plasticity, and the development of self-renewal capacities in TNBC.
  • Genomic instability in TNBC leads to mutations and copy number variations, while epigenetic remodeling influences gene expression profiles, contributing to pathogenesis and therapeutic resistance.

Purpose of the Study:

  • To review the multifaceted roles of epigenetics in triple-negative breast carcinogenesis.
  • To explore the landscape of transcriptomics in understanding TNBC behavior and its cellular microenvironment.
  • To highlight the potential applications of epigenetic and transcriptomic biomarkers in TNBC diagnosis, prognosis, and treatment decisions within molecular medicine.

Main Methods:

  • Review of current literature on epigenetics and transcriptomics in triple-negative breast cancer.
  • Analysis of molecular mechanisms including DNA methylation, histone modification, and noncoding RNAs.
  • Discussion of transcriptome analysis and its role in identifying biomarkers.

Main Results:

  • Epigenetic mechanisms are integral to the pathogenesis, maintenance, and therapeutic resistance of TNBC.
  • Transcriptome analysis provides insights into tumor behavior, cellular microenvironment, and potential biomarkers.
  • Understanding molecular changes driven by epigenetics and transcriptomics is essential for advancing TNBC treatment.

Conclusions:

  • Epigenetic modifications and transcriptomic alterations are fundamental to triple-negative breast cancer development and progression.
  • Biomarkers derived from epigenetic and transcriptomic studies hold significant promise for improving TNBC diagnosis, prognosis, and personalized treatment strategies.
  • Continued research in these areas is vital for developing more effective molecular medicine approaches to combat TNBC.
Keywords:
Epigenetic reprogrammingbiomarkersgenomic impulsivenesstranscriptometreatment decisiontriple negative breast cancer

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