Biomacromolecule-Functionalized Nanoparticle-Based Conjugates for Potentiation of Anticancer Therapy

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Cancer remains a major global health challenge, with conventional treatments facing limitations such as off-target toxicity and drug resistance.
• Existing advanced drug delivery systems like nanoparticles have shown potential but still grapple with issues like poor biocompatibility and stability.

Purpose of the Study:

• To explore the development of biomacromolecule-functionalized nanoconjugates for enhanced anticancer therapy.
• To review the potential of these nanoconjugates in treating various cancers, including lung, colorectal, ovarian, breast, and liver cancer.

Main Methods:

• Review of existing literature on biomacromolecule-functionalized nanoconjugates for cancer treatment.
• Analysis of the advantages offered by biofunctionalization in nanoconjugate design for drug delivery.

Main Results:

• Biomacromolecule-functionalized nanoconjugates demonstrate improved biocompatibility, site-specificity, and drug localization compared to conventional methods.
• These advanced carriers exhibit higher payload capacity, long-term stability, and reduced off-target toxicity.

Conclusions:

• Biomacromolecule-functionalized nanoconjugates represent a promising strategy for precision cancer therapy, enhancing the efficacy of therapeutic agents.
• Further research in this area is encouraged for the development of safer and more effective delivery systems for drugs, nutraceuticals, and phytoconstituents directly to the tumor microenvironment.