Related Experiment Video

Updated: Oct 11, 2025

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

2.0K

Intrapleural Hyaluronidase in Viscous Malignant Mesothelioma Pleural Effusion

Chuan T Foo1, Anna Paterson2, Adam Duckworth2

  • 1Department of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England.

Chest
|December 7, 2021
PubMed

Insights

This study reports a novel treatment for viscous malignant pleural effusion in mesothelioma patients. Intrapleural hyaluronidase effectively reduced fluid viscosity and drainage time, offering a safe management option.

Area of Science:

  • Oncology
  • Pulmonology
  • Biochemistry

Background:

  • Malignant pleural effusion is a frequent complication of mesothelioma.
  • Viscous effusions can complicate management and prolong treatment.
  • Hyaluronic acid is a key component contributing to effusion viscosity.

Observation:

  • A case of recurrent, viscous malignant pleural effusion in a mesothelioma patient is presented.
  • The effusion's high viscosity was attributed to hyaluronic acid, leading to prolonged drainage.
  • Standard management strategies were challenging due to the effusion's viscosity.

Findings:

  • Intrapleural administration of hyaluronidase was employed to address the viscous effusion.
  • Hyaluronidase treatment significantly decreased the pleural fluid viscosity.
  • This resulted in a marked reduction in the duration of pleural fluid drainage.

Implications:

  • Intrapleural hyaluronidase is a feasible and safe therapeutic option for hyaluronic acid-rich viscous malignant pleural effusion.
  • This approach may improve patient outcomes and reduce hospital stays.
  • Further research into hyaluronidase for managing complex pleural effusions is warranted.
Keywords:
hyaluronic acidhyaluronidasemalignant pleural effusionmesotheliomaviscous pleural effusion

More Related Videos

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

7.0K
Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion03:22

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion

Published on: November 10, 2023

978

Related Concept Videos

Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
319
Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
2.3K
Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
352
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
3.6K