Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
Skin Cancer01:30

Skin Cancer

4.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.9K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.5K
Experimental RNAi02:15

Experimental RNAi

6.4K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.4K
MicroRNAs01:22

MicroRNAs

3.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.2K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic modification of the marine-derived yeast Yarrowia lipolytica with high-protein content using a GPI-anchor-fusion expression system.

Biotechnology progress·2009
Same author

Regulation of the Edwardsiella tarda hemolysin gene and luxS by EthR.

Journal of microbiology and biotechnology·2009
Same author

EBV LMP2A-specific T cell immune responses elicited by dendritic cells loaded with LMP2A protein.

Cellular & molecular immunology·2009
Same author

[Combination of volar buttress plate with external fixator for the distal radial fractures of type C3 caused by high-energy injuries].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2009
Same author

Environmental regulation of floral anthocyanin synthesis in Ipomoea purpurea.

Molecular ecology·2009
Same author

PI3K integrates the effects of insulin and leptin on large-conductance Ca2+-activated K+ channels in neuropeptide Y neurons of the hypothalamic arcuate nucleus.

American journal of physiology. Endocrinology and metabolism·2009

Related Experiment Video

Updated: Oct 11, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

733

Noncoding RNAs: emerging players in skin cancers pathogenesis.

Lin Li1, Suliman Khan2,3, Song Li1

  • 1Department of Dermatology, The Affiliated Children's Hospital of Zhengzhou University Zhengzhou 450053, Henan, China.

American Journal of Cancer Research
|December 7, 2021
PubMed
Summary

This review explores noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, in skin cancer development. Understanding these molecules offers new diagnostic and therapeutic strategies for skin malignancies.

Keywords:
Skin cancercircRNAlncRNAmicroRNA

More Related Videos

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.6K
In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
07:52

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

Published on: November 2, 2020

6.6K

Related Experiment Videos

Last Updated: Oct 11, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

733
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.6K
In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
07:52

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

Published on: November 2, 2020

6.6K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Skin malignancies are globally prevalent cancers with increasing incidence.
  • They are broadly categorized into melanoma and nonmelanoma types (basal cell carcinoma, squamous cell carcinoma).
  • The human genome contains a vast noncoding transcriptome, with noncoding RNAs playing crucial roles in cellular processes.

Purpose of the Study:

  • To review current research on the role of noncoding RNAs in skin cancer pathogenesis.
  • To highlight microRNAs, long noncoding RNAs, and circular RNAs as key players in skin malignancies.
  • To explore the potential of noncoding RNAs as diagnostic and therapeutic targets for skin cancers.

Main Methods:

  • Literature review of current studies on noncoding RNAs and skin cancer.
  • Analysis of the involvement of microRNAs, long noncoding RNAs, and circular RNAs in skin cancer development.
  • Synthesis of findings regarding the functional roles of these noncoding RNAs.

Main Results:

  • Alterations in noncoding RNA expression are intrinsically linked to human cancers, including skin malignancies.
  • MicroRNAs, long noncoding RNAs, and circular RNAs are significantly involved in the pathogenesis of skin cancers.
  • Investigating the noncoding transcriptome provides insights into cancer mechanisms.

Conclusions:

  • Noncoding RNAs are critical regulators of cellular processes and are implicated in skin cancer development.
  • Targeting noncoding RNAs presents a promising avenue for novel diagnostic and therapeutic strategies in dermatology and oncology.
  • Further research into noncoding RNAs can advance our understanding and treatment of skin malignancies.