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Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
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Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling

Published on: October 28, 2014

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Deregulation of ribosomal proteins in human cancers

Wendy El Khoury1, Zeina Nasr1

  • 1Department of Biology, Faculty of Arts and Sciences, University of Balamand, Lebanon.

Bioscience Reports
|December 7, 2021
PubMed

Insights

Ribosomal proteins (RPs) have crucial roles beyond protein synthesis, impacting cancer development. This review explores how RP deregulation affects tumor cell fate in various cancers.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Ribosomes are essential for protein synthesis, comprising ribosomal RNAs (rRNAs) and ribosomal proteins (RPs).
  • Ribosomal proteins possess diverse extraribosomal functions beyond their structural role in ribosomes.
  • Dysregulation of RPs is increasingly linked to pathological processes, particularly tumorigenesis and cellular transformation.

Purpose of the Study:

  • To review recent advances concerning the deregulation of ribosomal proteins in various cancer types.
  • To elucidate the specific roles of ribosomal proteins in regulating tumor cell fate.
  • To highlight the pathological implications of RP dysregulation in cancer.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies focusing on ribosomal protein function and cancer.
  • Synthesis of findings on RP deregulation and its impact on tumor biology.

Main Results:

  • RPs exhibit significant extraribosomal functions that influence cellular processes.
  • Aberrant expression or function of RPs is a common feature in many cancers.
  • RPs play critical roles in key aspects of tumor cell fate, including proliferation, apoptosis, and metastasis.

Conclusions:

  • Ribosomal protein deregulation is a significant factor in cancer pathogenesis.
  • Targeting RPs or their functions presents potential therapeutic strategies for cancer treatment.
  • Further research into the multifaceted roles of RPs is crucial for understanding and combating cancer.
Keywords:
CancerRibosomesapoptosiscell survivalmetastasisribosomal proteins

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