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Related Experiment Videos

Endoneurial capillary permeability to [14C]sucrose in frog sciatic nerve.

A Weerasuriya, S I Rapoport

    Brain Research
    |June 4, 1986
    PubMed
    Summary

    Frog sciatic nerve capillaries act as an effective blood-nerve barrier, limiting water-soluble molecule passage. Permeability measurements show these capillaries are less permeable than most, but more than rat cerebral capillaries.

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    Brain research·1995

    Area of Science:

    • Neuroscience
    • Physiology
    • Vascular Biology

    Background:

    • The blood-nerve barrier (BNB) protects the nervous system.
    • Understanding endoneurial capillary permeability is crucial for BNB function.

    Purpose of the Study:

    • To quantify the permeability-surface area product (PA) of [14C]sucrose in frog endoneurial capillaries.
    • To assess the role of endoneurial capillaries in the blood-nerve barrier.

    Main Methods:

    • In situ perfusion technique.
    • Measurement of [14C]sucrose permeability-surface area product (PA).
    • Determination of vascular space percentage.

    Main Results:

    • The [14C]sucrose PA was measured at 6.6 x 10(-5) s-1.
    • Vascular space was determined to be 1.31%.
    • Sucrose permeability was lower than in most barrier tissues but higher than rat cerebral capillaries.

    Conclusions:

    • Endoneurial capillaries form an effective barrier to water-soluble non-electrolytes.
    • Findings align with capillary impermeability to microperoxidase and observed ultrastructure.
    • These capillaries contribute significantly to the blood-nerve barrier's integrity.

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