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Management of Ascending Aorta and Aortic Arch: Similarities and Differences Among Cardiovascular Guidelines
Konstantinos Spanos1,2, Petroula Nana1, Yskert von Kodolitsch2
1Department of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Insights
Current cardiovascular guidelines show inconsistencies in managing ascending aorta and aortic arch diseases. More research is needed to establish clear recommendations, especially regarding endovascular techniques for these aortic conditions.
Area of Science:
- Cardiovascular Medicine
- Thoracic Surgery
- Medical Guidelines
Background:
- Ascending aorta and aortic arch diseases are of growing interest to cardiovascular specialists.
- Innovations in endovascular and open surgery have expanded treatment options for complex aortic conditions.
- This review analyzes current cardiovascular guidelines for ascending aorta and aortic arch diseases.
Purpose of the Study:
- To systematically review and analyze current cardiovascular guidelines.
- To identify overlaps and differences in recommendations for ascending aorta and aortic arch diseases.
- To assess the evidence base supporting guideline recommendations.
Main Methods:
- Systematic literature search of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (January 2009-December 2020).
- Analysis of recommendations on definitions, diagnosis, indications for treatment, and management of ascending aorta and aortic arch diseases.
- Inclusion of 5 multidisciplinary cardiovascular society guidelines published between 2010 and 2019.
Main Results:
- Lack of a clear definition for non-A-non-B aortic dissection in most guidelines.
- Disagreement on recommendation class and evidence level for ascending aorta diameter as an indication for treatment.
- Limited evidence and inconsistent recommendations for endovascular techniques and aortic arch disease management.
Conclusions:
- Current guidelines predominantly favor open surgery for ascending aorta and aortic arch diseases.
- Recommendations are largely based on expert opinion, with limited integration of endovascular techniques.
- Heterogeneity, inconsistency in evidence levels, and a need for more robust data are evident.
Background:
Ascending aorta and aortic arch diseases have an increasing interest among cardiovascular specialists regarding diagnosis and management. Innovations in endovascular surgery and evolution of open surgery have extended the indications for treatment in patients previously considered unfit for surgery. The aim of this systematic review of the literature was to present and analyze current cardiovascular guidelines for overlap and differences in their recommendations regarding ascending aorta and aortic arch diseases and the assessment of evidence.
Methods:
The English medical literature was searched using the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases from January 2009 to December 2020. Recommendations on selected topics were analyzed, including issues from definitions and diagnosis (imaging and biomarkers) and indications for treatment to management, including surgical techniques, of the most important ascending aorta and aortic arch diseases.
Results:
The initial search identified 2414 articles. After exclusion of duplicate or inappropriate articles, the final analysis included 5 articles from multidisciplinary, cardiovascular societies published between 2010 and 2019. The definition of non-A-non-B aortic dissection is lacking from most of the guidelines. There is a disagreement regarding the class of recommendation and level of evidence for the diameter of ascending aorta as an indication. The indication for treatment of aortic disease may be individualized in specific cases while the growth rate may also affect the decision making. The role of endovascular techniques has not been established in current guidelines except by 1 society. Supportive evidence level in the management of aortic arch diseases remains limited.
Conclusion:
In current recommendations of cardiovascular societies, the ascending aorta and aortic arch remain a domain of open surgery despite the introduction of endovascular techniques. Recommendations of the included societies are mostly based on expert opinion, and the role of endovascular techniques has been highlighted only from 1 society. The chronological heterogeneity apparent among guidelines and the inconsistency in evidence level should be also acknowledged. More data are needed to develop more solid recommendations for the ascending aorta and aortic arch diseases.
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