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Updated: Oct 11, 2025
09:04
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
776
Improving therapeutic resistance: beginning with targeting the tumor microenvironment
Xiao-Ying Guan1, Xiao-Li Guan2, Zuo-Yi Jiao3
1Pathology Department, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Journal of Chemotherapy (Florence, Italy)
|December 7, 2021
Summary
Targeting the tumor microenvironment (TME) is crucial for overcoming cancer treatment resistance and metastasis. Strategies focusing on TME components can improve therapeutic efficacy and reduce recurrence.
Area of Science:
- Oncology
- Cancer Biology
- Immunology
Background:
- The tumor microenvironment (TME) significantly influences cancer progression, metastasis, and treatment resistance.
- Understanding TME components is vital for developing effective cancer therapies.
Approach:
- This review examines the characteristics and functions of key TME matrix components.
- It elucidates the mechanisms through which these components contribute to drug resistance.
Key Points:
- The TME comprises various matrix components that critically affect cancer development and spread.
- Specific TME components are implicated in acquired drug resistance.
- Targeting the TME offers a promising strategy to combat treatment resistance.
Conclusions:
- Strategies targeting the TME can enhance treatment efficacy.
- Modulating the TME may reduce tumor metastasis and recurrence.
- Further research into TME-targeted therapies holds significant potential for improving patient outcomes.
Keywords:
Tumor microenvironmentchemotherapyimmunotherapytarget therapytherapeutic resistancetumor metastasisMore Related Videos
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