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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
Timothy M Errington1, Alexandria Denis1, Anne B Allison2
1Center for Open Science, Charlottesville, United States.
Elife
|December 7, 2021
Summary
This study details the outcomes of replicating preclinical cancer biology experiments. Many attempts faced challenges, highlighting difficulties in repeating scientific findings and assessing reproducibility in cancer research.
Area of Science:
- Preclinical Cancer Biology
- Scientific Reproducibility
Background:
- The Reproducibility Project: Cancer Biology aimed to replicate experiments from high-impact preclinical cancer studies.
- Previous phases reported on 18 of 29 targeted papers, with 17 published by eLife.
Purpose of the Study:
- To report the status and outcomes of replication attempts for the remaining 11 preclinical cancer biology papers.
- To provide evidence on the challenges and replicability of preclinical cancer experiments.
Main Methods:
- Replication experiments were initiated for 11 selected preclinical cancer biology papers.
- Experimental work was stopped or faced challenges in all 11 cases, preventing full completion.
Main Results:
- Four papers had experimental work stopped without outcomes.
- Two papers yielded incomplete outcomes due to unforeseen experimental challenges.
- Five papers had only partial experiments completed due to technical or methodological issues.
Conclusions:
- Repeating preclinical cancer biology experiments presents significant challenges.
- The outcomes underscore difficulties in achieving full experimental replication in this field.
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